Corpus ID: 36226440

athobiochemistry elective induction of IL-6 by aluminum-induced oxidative stress can be revented by selenium

@inproceedings{Viezelienea2013athobiochemistryEI,
  title={athobiochemistry elective induction of IL-6 by aluminum-induced oxidative stress can be revented by selenium},
  author={ale Viezelienea and Piet Beekhofc and Eric Gremmerc and Hiliaras Rodoviciusd and Ilona Sadauskienea and U. Jansenc and L Ivanova},
  year={2013}
}
In this study the acute toxic effects of aluminum (Al) on mice have been investigated, including the interactions of Al and selenium (Se). Focus was put on the systemic effects of (co)exposure to Al and Se as a reflection of the redox status in the liver, kidney and brain. Short-term exposure (16 h) to Al resulted in an increase in the systemic inflammation parameters IL-6 and PAI-1, whereas serum levels of TNFremained unaffected. The different response pattern of IL6 and TNFprobably indicates… Expand

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References

SHOWING 1-10 OF 33 REFERENCES
Protective effect of selenium on aluminium-induced oxidative stress in mouse liver in vivo.
TLDR
The results indicate that Se did not have a protective effect on Al-linked liver toxicity, but did ameliorate intracellular oxidative stress processes mediated by glutathione. Expand
Aluminum accumulation induced testicular oxidative stress and altered selenium metabolism in mice.
TLDR
It was suggested that altered metabolism of Se, further stimulated testicular SelP transcription that may compensate for the loss of SelP protein resulted from Al-induced oxidative damage. Expand
Specific antioxidant selenoproteins are induced in the heart during hypertrophy.
TLDR
The main response of the selenoproteome during hypertrophy does not involve increased GPX1, but increased GPx3 for reducing extracellular H( 2)O(2) and increasedGPx4, Trxrd1, and MsrB1 for minimizing intracellular oxidative damage. Expand
Aluminium administration is associated with enhanced hepatic oxidant stress that may be offset by dietary vitamin E in the rat
TLDR
Investigation of the effects of aluminium lactate administration on indices of hepatic oxidant stress, and the consequences of concomitant dietary vitamin E, in male albino Wistar rats found that aluminium toxicity may be mediated, at least in part, by free radical generation. Expand
Antioxidant effect of vitamin E and selenium on lipid peroxidation, enzyme activities and biochemical parameters in rats exposed to aluminium.
  • F. El-Demerdash
  • Chemistry, Medicine
  • Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2004
TLDR
VE and Se have beneficial effects and could be able to antagonize Al toxicity, and VE or Se in combination with Al partially or totally alleviated its toxic effects on the studied parameters. Expand
Aluminium toxicity and iron homeostasis.
TLDR
In an animal model of aluminum overload, the increases in tissue aluminium content were paralleled by elevations of tissue iron in the kidney, liver heart and spleen as well as in various brain regions, frontal, temporal and parietal cortex and hippocampus, supporting previous studies which found little evidence for aluminium storage within ferritin. Expand
The genotoxic, hepatotoxic, nephrotoxic, haematotoxic and histopathological effects in rats after aluminium chronic intoxication
TLDR
Subchronic exposure to low doses of Al can produce serious dysfunctions in rat blood, liver and kidney, and exposure to this metal can result in greater damages. Expand
IL-6-deficient Mice Are Susceptible to Ethanol-induced Hepatic Steatosis: IL-6 Protects against Ethanol-induced Oxidative Stress and Mitochondrial Permeability Transition in the Liver
TLDR
IL-6 protects against ethanol-induced oxidative stress and mitochondrial dysfunction in hepatocytes via induction of metallothionein protein expression, which may account for the protective role of IL-6 in alcoholic liver disease. Expand
Age-related loss of associations between acute exercise-induced IL-6 and oxidative stress.
IL-6 mediates many aspects of the exercise-induced acute-phase response, including upregulation of antioxidant defenses. Moreover, IL-6 synthesis is regulated in part by oxidative stress. ThisExpand
Aluminum exposure affects transferrin-dependent and -independent iron uptake by K562 cells.
TLDR
It is demonstrated that Al modified Fe uptake without affecting the expression of Tf receptors, and proposed that Al interference with TfR-mediated Fe incorporation might trigger the upregulation of NTBI uptake, an adaptation aimed at incorporating the essential metal required for cellular metabolism without allowing the simultaneous access of a potentially toxic metal. Expand
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