as a Novel Tumor Suppressor in Lung Cancer β Factor 3 Binding Protein Targets Identifies Hepatocyte Nuclear A Transcriptional Profiling Study of CCAAT / Enhancer

@inproceedings{Halmos2004asAN,
  title={as a Novel Tumor Suppressor in Lung Cancer β Factor 3 Binding Protein Targets Identifies Hepatocyte Nuclear A Transcriptional Profiling Study of CCAAT / Enhancer},
  author={Balazs Halmos and Daniela Sanchez Bass{\`e}res and Stephano Monti and Francesco D ‘ Al{\'o} and Tajhal Dayaram and Katalin Ferenczi and Bas J. Wouters and Claudia S. Huettner and Todd R. Golub and Daniel G Tenen},
  year={2004}
}
We showed previously that CCAAT/enhancer binding protein (C/ EBP ), a tissue-specific transcription factor, is a candidate tumor suppressor in lung cancer. In the present study, we have performed a transcriptional profiling study of C/EBP target genes using an inducible cell line system. This study led to the identification of hepatocyte nuclear factor 3 (HNF3 ), a transcription factor known to play a role in airway differentiation, as a downstream target of C/EBP . We found downregulation of… CONTINUE READING

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