• Corpus ID: 45990061

articleAltered microRNA expression profile with miR-146 a upregulation in CD 4 + T cells from patients with rheumatoid arthritis

  title={articleAltered microRNA expression profile with miR-146 a upregulation in CD 4 + T cells from patients with rheumatoid arthritis},
  author={Jingyi Li and Ying Wan and Qiuye Guo and Liyun Zou and Jinyu Zhang and Yongfei Fang and Jingbo Zhang and Jinjun Zhang and Xiao-lan Fu and Hongli Liu and Liwei Lu and Yuzhang Wu},
Introduction: Increasing evidence indicates that microRNAs (miRNAs) play a critical role in the pathogenesis of inflammatory diseases. The aim of the study was to investigate the expression pattern and function of miRNAs in CD4+ T cells from patients with rheumatoid arthritis (RA). Methods: The expression profile of miRNAs in CD4+ T cells from synovial fluid (SF) and peripheral blood of 33 RA patients was determined by microarray assay and validated by qRT-PCR analysis. The correlation between… 
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