ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression.

@article{Zhang2010ampGGO,
  title={ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression.},
  author={Ying Zhang and Qiyu Bao and Luc Gagnon and Ann Huletsky and Antonio Oliver and Shouguang Jin and Taimour Y Langaee},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 11},
  pages={4772-9}
}
In enterobacteria, the ampG gene encodes a transmembrane protein (permease) that transports 1,6-GlcNAc-anhydro-MurNAc and the 1,6-GlcNAc-anhydro-MurNAc peptide from the periplasm to the cytoplasm, which serve as signal molecules for the induction of ampC β-lactamase. The role of AmpG as a transporter is also essential for cell wall recycling. Pseudomonas aeruginosa carries two AmpG homologues, AmpG (PA4393) and AmpGh1 (PA4218), with 45 and 41% amino acid sequence identity, respectively, to… CONTINUE READING
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