alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells.

@article{Albert2000alphavbeta5IR,
  title={alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells.},
  author={Matthew L Albert and Jae Il Kim and Raymond B Birge},
  journal={Nature cell biology},
  year={2000},
  volume={2 12},
  pages={899-905}
}
Integrin receptors are important for the phagocytosis of apoptotic cells. However, little is known about their function in mediating internalization, as previous studies used blocking antibodies for the inhibition of binding. Here we show that the alphavbeta5 receptor mediates both binding and internalization of apoptotic cells. Internalization is dependent… CONTINUE READING