alphavbeta3- and alpha5beta1-integrin blockade inhibits myogenic constriction of skeletal muscle resistance arterioles.

@article{MartinezLemus2005alphavbeta3AA,
  title={alphavbeta3- and alpha5beta1-integrin blockade inhibits myogenic constriction of skeletal muscle resistance arterioles.},
  author={Luis A. Martinez-Lemus and Tracy Y Crow and Michael J Davis and Gerald A. Meininger},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 1},
  pages={H322-9}
}
In isolated resistance arterioles with spontaneous tone, ligation of alpha4beta1- and alpha5beta1-integrins induces vasoconstriction whereas ligation of alphavbeta3-integrin induces vasodilation. However, whether integrins directly participate in myogenic constriction to pressure elevation is not known. To answer this question, isolated rat skeletal muscle arterioles were exposed to step increments in pressure in the absence or presence of peptides and function-blocking antibodies known to bind… CONTINUE READING

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