alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.

@article{Janssens2001alphaTcateninAN,
  title={alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.},
  author={Barbara Janssens and Steven Goossens and Katrien Staes and Brian Gilbert and Jolanda van Hengel and Cecile G A Colpaert and Erik A. Bruyneel and Marc Mareel and Frans van Roy},
  journal={Journal of cell science},
  year={2001},
  volume={114 Pt 17},
  pages={3177-88}
}
Cadherins are major cell-cell adhesion proteins whose cytoplasmic domains bind to catenin proteins. Strong intercellular adhesion depends on linkage of the cadherin/catenin complex to the actin cytoskeleton via alpha-catenin. To date, it is not clear how different cell types achieve the variable strength of cell-cell adhesion clearly needed in a multicellular organism. Here, we report the cloning and molecular characterization of alphaT(testis)-catenin, a novel human cDNA encoding a protein… CONTINUE READING

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