alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol.

@article{Walker2008alpha1noradrenergicRA,
  title={alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol.},
  author={Brendan Walker and Dennis Rasmussen and Murray A. Raskind and George F. Koob},
  journal={Alcohol},
  year={2008},
  volume={42 2},
  pages={91-7}
}
The purpose of this study was to test the hypothesis that blockade of alpha1-adrenergic receptors may suppress the excessive ethanol consumption associated with acute withdrawal in ethanol-dependent rats. Following the acquisition and stabilization of operant ethanol self-administration in male Wistar rats, dependence was induced in half the animals by subjecting them to a 4-week intermittent vapor exposure period in which animals were exposed to ethanol vapor for 14h/day. Subsequent to… CONTINUE READING

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Effects of moderate alcohol consumption on the central nervous system

  • B. M. Walker
  • Alcohol
  • 2008

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