• Medicine
  • Published in
    Sheng li xue bao : [Acta…
    2007

alpha1-adrenergic receptors activate AMP-activated protein kinase in rat hearts.

@article{Xu2007alpha1adrenergicRA,
  title={alpha1-adrenergic receptors activate AMP-activated protein kinase in rat hearts.},
  author={Ming Jiang Xu and Yanting Zhao and Yao Zu Song and Tian-Pao Hao and Zhi-zhen Lu and Qi-de Han and Shi-Qiang Wang and You-Yi Zhang},
  journal={Sheng li xue bao : [Acta physiologica Sinica]},
  year={2007},
  volume={59 2},
  pages={
          175-82
        }
}
To test the hypothesis that AMP-activated protein kinase (AMPK) is possibly the downstream signaling molecule of certain subtypes of adrenergic receptor (AR) in the heart, we evaluated AMPK activation mediated by ARs in H9C2 cells, a rat cardiac source cell line, and rat hearts. [...] Key ResultsAt the cellular level, we found that NE elevated AMPK phosphorylation level in a dose-and time-dependent manner, with the maximal effect at 10 μmol/L NE after 10-minute treatment. Expand Abstract

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Role of AMP-activated protein kinase in healthy and diseased hearts.

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  • 2006