alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength.

@article{Thiagarajan2002alphaAB,
  title={alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength.},
  author={Tara C. Thiagarajan and Erika S. Piedras-Renter{\'i}a and Richard W. Tsien},
  journal={Neuron},
  year={2002},
  volume={36 6},
  pages={1103-14}
}
We show that alpha and betaCaMKII are inversely regulated by activity in hippocampal neurons in culture: the alpha/beta ratio shifts toward alpha during increased activity and beta during decreased activity. The swing in ratio is approximately 5-fold and may help tune the CaMKII holoenzyme to changing intensities of Ca(2+) signaling. The regulation of CaMKII levels uses distinguishable pathways, one responsive to NMDA receptor blockade that controls alphaCaMKII alone, the other responsive to… CONTINUE READING
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