alpha- and beta-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes.

@article{IwaiKanai1999alphaAB,
  title={alpha- and beta-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes.},
  author={Eri Iwai-Kanai and Koji Hasegawa and Makoto Araki and Tsuyoshi Kakita and Tatsuya Morimoto and Shigetake Sasayama},
  journal={Circulation},
  year={1999},
  volume={100 3},
  pages={
          305-11
        }
}
BACKGROUND The apoptosis of cardiac myocytes may play a role in the development of heart failure. Norepinephrine is one of the factors activated in heart failure and can induce myocardial cell apoptosis in culture. However, it is unknown if alpha- and beta-adrenergic pathways coordinately or differentially regulate apoptosis and if this apoptotic pathway uses common or cell type-specific apoptotic signals. METHODS AND RESULTS We stimulated cultured neonatal rat cardiac myocytes with an alpha… CONTINUE READING
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