alpha-Tocopherol enhances degranulation in RBL-2H3 mast cells.

@article{Hemmerling2010alphaTocopherolED,
  title={alpha-Tocopherol enhances degranulation in RBL-2H3 mast cells.},
  author={Jana Hemmerling and Sandra Nell and Anna Patricia Kipp and Sara Schumann and Stefanie Deubel and Michael Haack and Regina Brigelius-Floh{\'e}},
  journal={Molecular nutrition & food research},
  year={2010},
  volume={54 5},
  pages={652-60}
}
Based on the observation that 3 months alpha-tocopherol supplementation caused an up-regulation of the mRNA of vesicular transport proteins in livers of mice, the functional relevance was investigated in RBL-2H3 cells, a model for mast cell degranulation. In total, 24 h incubation with 100 muM alpha-tocopherol enhanced the basal and phorbol-12-myristyl-13… CONTINUE READING