alpha-Tocopherol disturbs macrophage LXRalpha regulation of ABCA1/G1 and cholesterol handling.

Abstract

Based on the oxidation hypothesis high doses of alpha-tocopherol have been advocated to prevent atherosclerosis, but clinical trials failed to demonstrate a benefit. As specific oxylipids activate PPARgamma and LXRalpha, master regulators of lipid metabolism and cholesterol exporters, we hypothesized, that high dose alpha-tocopherol might interfere with… (More)
DOI: 10.1016/j.bbrc.2008.02.132

Topics

Cite this paper

@article{Rode2008alphaTocopherolDM, title={alpha-Tocopherol disturbs macrophage LXRalpha regulation of ABCA1/G1 and cholesterol handling.}, author={Sabine Rode and Tina Rubic and Reinhard L. Lorenz}, journal={Biochemical and biophysical research communications}, year={2008}, volume={369 3}, pages={868-72} }