Corpus ID: 11067298

alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release.

@article{Freedman2000alphaTocopherolAP,
  title={alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release.},
  author={J. Freedman and L. Li and R. Sauter and JF J.R.Keaney},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2000},
  volume={14 15},
  pages={
          2377-9
        }
}
  • J. Freedman, L. Li, +1 author J. R. Keaney JF
  • Published 2000
  • Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Platelet activation is tightly regulated by products of the endothelium and platelets including nitric oxide (NO). Excess vascular oxidative stress has been associated with impaired NO release, and antioxidant status has been shown to alter endothelium-derived NO bioactivity. Although physiological levels of a-tocopherol are known to inhibit platelet function, the effect of a-tocopherol on platelet NO release is unknown. Loading platelets with physiologic levels of a-tocopherol increased… Expand
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