alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity.

Abstract

Because a limited study previously showed that alpha-synuclein (alpha-syn), the major pathogenic protein for Parkinson disease, was expressed in differentiating brain tumors as well as various peripheral cancers, the main objective of the present study was to determine whether alpha-syn might be involved in the regulation of tumor differentiation. For this… (More)

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@article{Fujita2007alphaSynucleinSD, title={alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity.}, author={Masayo Fujita and Shuei Sugama and Masaaki Nakai and Takato Takenouchi and Jianshe Wei and Tomohiko Urano and Satoshi Inoue and Makoto Hashimoto}, journal={The Journal of biological chemistry}, year={2007}, volume={282 8}, pages={5736-48} }