alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter.

@article{Pifl2004alphaSynucleinSI,
  title={alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter.},
  author={Christian Pifl and Maya Khorchide and Alexandra Kattinger and Harald Reither and John S. Hardy and Oleh Hornykiewicz},
  journal={Neuroscience letters},
  year={2004},
  volume={354 1},
  pages={34-7}
}
The established or potentially toxic agents implicated in the nigral cell death in Parkinson's disease, dopamine, 1-methyl-4-phenylpyridinium (MPP(+)), iron, and manganese, were examined as to their effects on the viability of cells overexpressing alpha-synuclein. SK-N-MC neuroblastoma cells stably expressing the human dopamine transporter were transfected with human alpha-synuclein and cell clones with and without alpha-synuclein immunoreactivity were obtained. Cells were exposed for 24-72 h… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

The role of environmental exposures in neurodegeneration and neurodegenerative diseases.

Toxicological sciences : an official journal of the Society of Toxicology • 2011
View 2 Excerpts

Similar Papers

Loading similar papers…