alpha-Synuclein filaments bind the transcriptional regulator HMGB-1.

  title={alpha-Synuclein filaments bind the transcriptional regulator HMGB-1.},
  author={Evo K Lindersson and Peter H\ojrup and Wei Ping Gai and Daniel Locker and Davy Martin and Poul Henning Jensen},
  volume={15 18},
Abnormal accumulation of alpha-synuclein filaments in Lewy bodies is a neuropathological hallmark of Parkinson's disease and sequestration of cellular protein into these protein aggregates may contribute to the degenerative process. We identified the transcriptional co-factor high mobility group protein 1 (HMGB-1) as a ligand for alpha-synuclein filaments by a filament spin-down technique, mass spectrometric peptide mapping and immunoblotting. HMGB-1 binds preferentially to aggregated alpha… CONTINUE READING
13 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…