alpha-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells.

@article{Kamierczak2008alphaSynucleinES,
  title={alpha-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells.},
  author={Anna Kaźmierczak and Joanna Benigna Strosznajder and Agata Adamczyk},
  journal={Neurochemistry international},
  year={2008},
  volume={53 6-8},
  pages={263-9}
}
alpha-Synuclein is the fundamental component of Lewy bodies which occur in the brain of 60% of sporadic and familial Alzheimer's disease patients. Moreover, a proteolytic fragment of alpha-synuclein, the so-called non-amyloid component of Alzheimer's disease amyloid, was found to be an integral part of Alzheimer's dementia related plaques. However, the role of alpha-synuclein in pathomechanism of Alzheimer's disease remains elusive. In particular, the relationship between alpha-synuclein and… CONTINUE READING

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