alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation.

@article{Santostefano1993alphaNaphthoflavoneinducedCG,
  title={alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation.},
  author={M Santostefano and Melinda Merchant and Luz Arellano and Vivienne Morrison and Michael S. Denison and Stephen Safe},
  journal={Molecular pharmacology},
  year={1993},
  volume={43 2},
  pages={200-6}
}
alpha-Naphthoflavone (alpha NF) is a weak aryl hydrocarbon (Ah) receptor agonist and inhibits the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. It has been suggested that the Ah receptor antagonist activity is due to the formation of alpha NF-cytosolic Ah receptor complexes that fail to undergo transformation. This hypothesis is consistent with data obtained in this and other studies using alpha NF concentrations from 10 to 1000 nM. However, 10 microM alpha NF… CONTINUE READING