alpha-Methylacyl-CoA racemase: expression levels of this novel cancer biomarker depend on tumor differentiation.

@article{Kuefer2002alphaMethylacylCoARE,
  title={alpha-Methylacyl-CoA racemase: expression levels of this novel cancer biomarker depend on tumor differentiation.},
  author={Rainer Kuefer and Sooryanarayana Varambally and Ming Zhou and Peter C. Lucas and Martin L{\"o}ffler and Hubertus Wolter and Torsten Mattfeldt and Richard E. Hautmann and J{\"u}rgen Erich Gschwend and Terrence R. Barrette and Rodney L. Dunn and Arul M. Chinnaiyan and Mark A. Rubin},
  journal={The American journal of pathology},
  year={2002},
  volume={161 3},
  pages={841-8}
}
alpha-Methylacyl-CoA racemase (AMACR) has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression was down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR. To further explore the hypothesis that AMACR is hormone regulated and plays a role in PCa progression AMACR protein expression was characterized in a broad range of PCa… CONTINUE READING