alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes.

@article{AbdelMalek2009alphaMSHTA,
  title={alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes.},
  author={Zalfa A Abdel-Malek and Andrew R Ruwe and Renny Kavanagh-Starner and Ana Luisa Kadekaro and Viki B. Swope and Carrie Haskell-Luevano and Leonid Koikov and James J. Knittel},
  journal={Pigment cell & melanoma research},
  year={2009},
  volume={22 5},
  pages={635-44}
}
One skin cancer prevention strategy that we are developing is based on synthesizing and testing melanocortin analogs that reduce and repair DNA damage resulting from exposure to solar ultraviolet (UV) radiation, in addition to stimulating pigmentation. Previously, we reported the effects of tetrapeptide analogs of alpha-melanocortin (alpha-MSH) that were more potent and stable than the physiological alpha-MSH, and mimicked its photoprotective effects against UV-induced DNA damage in human… CONTINUE READING

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