alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.

@article{Sdhof2001alphaLatrotoxinAI,
  title={alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.},
  author={T. S{\"u}dhof},
  journal={Annual review of neuroscience},
  year={2001},
  volume={24},
  pages={
          933-62
        }
}
  • T. Südhof
  • Published 2001
  • Medicine, Biology
  • Annual review of neuroscience
  • alpha-Latrotoxin, a potent neurotoxin from black widow spider venom, triggers synaptic vesicle exocytosis from presynaptic nerve terminals. alpha-Latrotoxin is a large protein toxin (120 kDa) that contains 22 ankyrin repeats. In stimulating exocytosis, alpha-latrotoxin binds to two distinct families of neuronal cell-surface receptors, neurexins and CLs (Cirl/latrophilins), which probably have a physiological function in synaptic cell adhesion. Binding of alpha-latrotoxin to these receptors does… CONTINUE READING
    α-Latrotoxin and Its Receptors
    • 61
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 152 REFERENCES
    α-Latrotoxin Stimulates Exocytosis by the Interaction with a Neuronal G-Protein-Coupled Receptor
    • 290
    • Highly Influential
    Neurexins Are Functional α-Latrotoxin Receptors
    • 90