alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies.

  title={alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies.},
  author={Michele Caraglia and Alessandro Leardi and B. Ricciardi and M Delaurentiis and M Graziano and Elide Matano and S Deplacido and A. Raffaele Bianco and Pierosandro Tagliaferri},
  journal={International journal of oncology},
  volume={8 5},
We have demonstrated that interferon-alpha 2 recombinant (IFN alpha) inhibits the growth and modulates the expression of the receptor for transferrin (TRF-R) in human epidermoid carcinoma KB cells. Receptor upregulation results in the reconstitution of intracellular iron levels in the IFN alpha-treated cells. Several anti-TRF-R murine monoclonal antibodies (MAbs) have been generated which induce tumor cell growth inhibition through blockade of receptor function. We have evaluated by MTT assay… Expand
Desferioxamine increases iron depletion and apoptosis induced by ara‐C of human myeloid leukaemic cells
It is found that desferioxamine strongly potentiated the effects of ara‐C on leukaemic cell growth inhibition and apoptosis, the first report of a positive interaction between aRA‐C and an iron chelator in terms of antileukaemic effects. Expand
Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation.
The novel insights on the biochemical and molecular events leading to protein biosynthesis are reviewed and their involvement in cell proliferation and tumorigenesis are described and a new multimodal strategy is proposed based on the simultaneous intervention on protein synthesis and signal transduction. Expand