alpha-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surface.

@article{Bergmann2001alphaEnolaseOS,
  title={alpha-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surface.},
  author={Simone Bergmann and Manfred Rohde and Gursharan Singh Chhatwal and Sven Hammerschmidt},
  journal={Molecular microbiology},
  year={2001},
  volume={40 6},
  pages={1273-87}
}
Binding of human plasminogen to Streptococcus pneumoniae and its subsequent activation promotes penetration of bacteria through reconstituted basement membranes. In this study, we have characterized a novel pneumococcal surface protein with a molecular mass of 47 kDa, designated Eno, which specifically binds human plasmin(ogen), exhibits alpha-enolase activity and is necessary for viability. Using enzyme assays, we have confirmed the alpha-enolase activity of both pneumococcal surface-displayed… CONTINUE READING
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