alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling.

@article{Inge2008alphaCateninOS,
  title={alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling.},
  author={Landon J. Inge and Sigrid A. Rajasekaran and Daniel G Wolle and Sonali P Barwe and Sergey Vasilyevich Ryazantsev and Charles M. Ewing and William B Isaacs and Ayyappan K. Rajasekaran},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 6},
  pages={1386-97}
}
Loss of alpha-catenin is one of the characteristics of prostate cancer. The catenins (alpha and beta) associated with E-cadherin play a critical role in the regulation of cell-cell adhesion. Tyrosine phosphorylation of beta-catenin dissociates it from E-cadherin and facilitates its entry into the nucleus, where beta-catenin acts as a transcriptional activator inducing genes involved in cell proliferation. Thus, beta-catenin regulates cell-cell adhesion and cell proliferation. Mechanisms… CONTINUE READING
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