• DOI:10.1099/MIC.0.27037-0
Corpus ID: 25416966

alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus.

@article{Miyazaki2004alphaAminoadipateAF,
  title={alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus.},
  author={T. Miyazaki and J. Miyazaki and H. Yamane and M. Nishiyama},
  journal={Microbiology},
  year={2004},
  volume={150 Pt 7},
  pages={
          2327-34
        }
}

• T. Miyazaki, J. Miyazaki, +1 author M. Nishiyama
• Published 2004
• Biology, Medicine
• Microbiology

The extremely thermophilic bacterium Thermus thermophilus HB27 synthesizes lysine through alpha-aminoadipate (AAA). In this study, a T. thermophilus gene encoding the enzyme that catalyses transamination of AAA was cloned as a mammalian kynurenine/AAA aminotransferase (Kat2) gene homologue. A T. thermophilus mutant with disruption of the Kat2 homologue required a longer lag phase for growth and showed slower growth in minimal medium. Furthermore, addition of AAA or lysine shortened the lag… Expand