alpha-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents.

Abstract

In a program to identify new anti-ulcer compounds, a series of N-acyl derivatives of alpha-amino acids were screened for their in vitro H(+)/K(+) ATPase inhibitory activity, and in vivo efficacy in Pylorus ligation model. 3D-QSAR studies were carried out and a representative compound 13 was studied for the nature of its proton pump inhibition.

Cite this paper

@article{Sharma2007alphaAminoAD, title={alpha-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents.}, author={Preeti Sharma and Sangeeta B Singh and Tanveer I Siddiqui and Vishnu Singh and Bijoy Kundu and Philip Prathipati and Anil K. Saxena and Dinesh Kumar Dikshit and Leena Rastogi and Chetna Dixit and Meenal Gupta and Gyanendra K. Patnaik and Madhu Dikshit}, journal={European journal of medicinal chemistry}, year={2007}, volume={42 3}, pages={386-93} }