alpha 2-Adrenoceptor agonists induced mydriasis in the rat by an action within the central nervous system.

@article{Berridge1983alpha2A,
  title={alpha 2-Adrenoceptor agonists induced mydriasis in the rat by an action within the central nervous system.},
  author={T L Berridge and B Gadie and Alan G Roach and Ian F. Tulloch},
  journal={British journal of pharmacology},
  year={1983},
  volume={78 3},
  pages={507-15}
}
1 The effects of intravenous administration of the selective alpha 2-adrenoceptor agonists clonidine, UK 14,304 and guanoxabenz on rat pupil diameter were investigated. 2 In rats anaesthetized with pentobarbitone, each agonist produced a marked dose-related increase in pupil diameter; the rank order of potency was: clonidine greater than UK 14,304 greater than guanoxabenz. 3 Pretreatment with the selective alpha 2-adrenoceptor antagonist, RX 781094 (0.5 mg/kg, i.v.), produced a parallel 30-40… CONTINUE READING
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