alpha,beta-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases.

@article{Moretto2009alphabetaUnsaturatedAC,
  title={alpha,beta-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases.},
  author={Nadia Moretto and Fabrizio Facchinetti and Thomas Southworth and Maurizio Civelli and Dave Singh and Riccardo Patacchini},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2009},
  volume={296 5},
  pages={L839-48}
}
Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD), a syndrome characterized by pulmonary neutrophil infiltration, chronic inflammation, and progressive tissue destruction. We examined here the acute effect of aqueous cigarette smoke extract (CSE) and of two alpha,beta-unsaturated aldehydes (acrolein and crotonaldehyde) contained in CSE in cultured normal human lung fibroblasts and small airway epithelial cells. By examining a panel of 19 cytokines and… CONTINUE READING
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