a brain disease

  title={a brain disease},
  author={Abigail Shefer and Yonit Marcus and Naftali Stern},
That the brain is involved in the pathogenesis and perpetuation of obesity is broadly self-intuitive, but traditional evaluation of this relationship has focused on psychological and environment-dependent issues, often referred to as the “it’s all in the head” axiom. Here we review evidence that excessive nutrition or caloric flux, regardless of its primary trigger, elicits a biological trap which imprints aberrant energy control circuits that tend to worsen with the accumulation of body fat… 

A Neurobehavioral Approach to Addiction: Implications for the Opioid Epidemic and the Psychology of Addiction

The issue of predisposition or vulnerability to becoming addicted to drugs (i.e., the question of why some people who experiment with drugs develop an addiction, while others do not) is addressed.

Liking, wanting, and the incentive-sensitization theory of addiction.

The incentive-sensitization theory posits the essence of drug addiction to be excessive amplification specifically of psychological "wanting," especially triggered by cues, without necessarily an amplification of "liking."

Cardiometabolic profile of young women with hypoprolactinemia

The obtained results suggest that hypoprolactinemia in women of reproductive age may increase cardiometabolic risk.

Recognizing behavioral signs of pain and disease: a guide for practitioners.

  • D. Frank
  • Psychology
    The Veterinary clinics of North America. Small animal practice
  • 2014

Bladder, Bowel, and Sexual Dysfunction in Parkinson's Disease

The pathophysiology of the pelvic organ dysfunction in Parkinson's disease differs from that in multiple system atrophy; therefore, it might aid in differential diagnosis.

Methadone dosage and its relationship to quality of life, satisfaction, psychopathology, cognitive performance and additional consumption of non-prescribed drugs.

A negative relationship between dose and quality of life, psychopathological symptoms and cognitive performance is revealed, and the results reject the need for high dosage if not required by the patient, and highlight the benefits of other psychosocial interventions that lead to recovery.

Neurologic disease attributed to a pituitary adenoma in an alpaca.

A 14-year-old 80-kg castrated male Huacaya alpaca was evaluated because of a gradual onset of behavioral changes and an inflammatory or infectious disease process was suspected based on hyperfibrinogenemia and a leukocytosis characterized by neutrophilia with a regenerative left shift.

Vaccines against Vice: A constructive technology assessment of immunotherapies for addiction

This thesis examines the development of active immunotherapies or ‘vaccines’ for drug addiction, within the framework of constructive technology assessment. Drawing on post-structuralist and

Hidrocefalia congênita em cães Hydrocephalus Congenital in Dogs

The clinical signs in dogs found in this study were changes in behavior and level of consciousness, characterized by drowsiness and/or hallucinations, and the importance of congenital hydrocephalus in the differential diagnosis of young dogs with neurological signs of cortical thalamus was highlighted.

Systematic Review of Occupational Therapy in the Treatment of Addiction: Models, Practice, and Qualitative and Quantitative Research

Although occupational therapy has been involved in the treatment of people with substance addiction and, more recently, with behavioral addictions for more than half a century, the research that has been published is poor.



Cognitive and Emotional Alterations Are Related to Hippocampal Inflammation in a Mouse Model of Metabolic Syndrome

Behavioral alterations of db/db mice were associated with increased inflammatory cytokines and reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus but not the hypothalamus, which strongly point to interactions between cytokine and central processes involving the hippocampus as important contributing factor to the behavioral alterations ofdb/ db mice.

Mood Disorders and Obesity: Understanding Inflammation as a Pathophysiological Nexus

It is indicated that obesity and mood disorders are chronic low-grade pro-inflammatory states that result in a gradual accumulation of allostatic load and practitioners should screen individuals with obesity for the presence of clinically significant depressive symptoms.

A review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment

It is suggested that weight gain results, at least in part, from a neurological predisposition characterized by reduced executive function, and in turn obesity itself has a compounding negative impact on the brain via mechanisms currently attributed to low‐grade systemic inflammation, elevated lipids and/or insulin resistance.

Modifiable factors that alter the size of the hippocampus with ageing

Observational studies and preliminary clinical trials have raised the possibility that physical exercise, cognitive stimulation and treatment of general medical conditions can reverse age-related atrophy in the hippocampus, or even expand its size, and the dynamic polygon hypothesis suggests that treatment of modifiable risk factors can increase the volume or prevent atrophy of the hippocampus.

Leptin Replacement Improves Cognitive Development

Replacement with r-metHuLeptin is associated with weight loss and changes in rates of development in many neurocognitive domains, which lends support to the hypothesis that, in addition to its role in metabolism, leptin may have a cognitive enhancing role in the developing central nervous system.

Central obesity and the aging brain.

A larger waist-hip ratio may be related to neurodegenerative, vascular, or metabolic processes that affect brain structures underlying cognitive decline and dementia.

The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat.

The results indicate that hippocampal function may be particularly vulnerable to disruption by HE-diets, and this disruption may be related to impaired BBB integrity.

Hypertension and the brain: vulnerability of the prefrontal regions and executive functions.

Even controlled hypertension may be associated with deficits in brain structure and cognition, warranting further study.

FTO, obesity and the adolescent brain.

FTO is associated with shared inverse variance between body adiposity and brain volume, suggesting that this gene may exert inverse effects on adipose and brain tissues.