Zyxin mediation of stretch-induced gene expression in human endothelial cells.


RATIONALE Prolonged exposure to enhanced stretch, such as in hypertension, triggers endothelial dysfunction, a hallmark of pathological vascular remodeling processes. Despite its clinical relevance, little is known about stretch-induced gene expression in endothelial cells. OBJECTIVE Here, we have characterized a new stretch-inducible signaling pathway… (More)
DOI: 10.1161/CIRCRESAHA.110.227850

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