Zyxin is a novel interacting partner for SIRT1

  title={Zyxin is a novel interacting partner for SIRT1},
  author={Yuki Fujita and Atsushi Yamaguchi and Katsuhiko Hata and Mitsuharu Endo and Noritaka Yamaguchi and Toshihide Yamashita},
  journal={BMC Cell Biology},
  pages={6 - 6}
SIRT1 is a mammalian homologue of NAD+-dependent deacetylase sirtuin family. It regulates longevity in several model organisms and is involved with cell survival, differentiation, metabolism among other processes in mammalian cells. SIRT1 modulates functions of various key targets via deacetylation. Recent studies have revealed SIRT1 protects neurons from axonal degeneration or neurodegeneration. Further, SIRT1 null mice exhibit growth retardation and developmental defects, suggesting its… CONTINUE READING
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