Zyxin is a critical regulator of the apoptotic HIPK2-p53 signaling axis.

@article{Crone2011ZyxinIA,
  title={Zyxin is a critical regulator of the apoptotic HIPK2-p53 signaling axis.},
  author={Johanna Crone and Carolina Glas and Kathrin Schultheiss and Jutta Moehlenbrink and Eva Krieghoff-Henning and Thomas G. Hofmann},
  journal={Cancer research},
  year={2011},
  volume={71 6},
  pages={2350-9}
}
HIPK2 activates the apoptotic arm of the DNA damage response by phosphorylating tumor suppressor p53 at serine 46. Unstressed cells keep HIPK2 levels low through targeted polyubiquitination and subsequent proteasomal degradation. Here we identify the LIM domain protein Zyxin as a novel regulator of the HIPK2-p53 signaling axis in response to DNA damage. Remarkably, depletion of endogenous Zyxin, which colocalizes with HIPK2 at the cytoskeleton and in the cell nucleus, stimulates proteasome… CONTINUE READING