Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation.

@article{Jiang2013ZymosanAP,
  title={Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation.},
  author={Lily I Jiang and Paul C. Sternweis and Jack Wang},
  journal={Molecular immunology},
  year={2013},
  volume={54 1},
  pages={14-22}
}
Pathogens use a variety of strategies to evade host immune defenses. A powerful way to suppress immune function is to increase intracellular concentrations of cAMP in host immune cells, which dampens inflammatory responses and prevents microbial killing. We found that the yeast cell wall extract, zymosan, is capable of increasing intracellular cAMP and activates the protein kinase A pathway in bone marrow derived macrophage (BMDM) cells from mice. This response is dependent on adenylyl cyclase… CONTINUE READING
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