Zymographic detection and clinical correlations of MMP-2 and MMP-9 in breast cancer sera

  title={Zymographic detection and clinical correlations of MMP-2 and MMP-9 in breast cancer sera},
  author={Giampiero La Rocca and Ida Pucci-Minafra and Antonio Marrazzo and Piera Taormina and Salvatore Minafra},
  journal={British Journal of Cancer},
  pages={1414 - 1421}
Matrix metalloproteinases, in particular the gelatinases MMP-2 and MMP-9, have received great attention in recent years as putative tumour markers for clinical applications. The main reason for the observed interest is their easy detection in body fluids. Moreover, recent evidence has shown multiple functions of MMPs, rather than simply degrading ECM, which include the mobilisation of growth factors and processing of surface molecules. Several authors have reported increased levels of MMPs in a… CONTINUE READING


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