Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease.

Abstract

The proprotein convertase subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P) plays crucial roles in cellular homeostatic functions and is hijacked by pathogenic viruses for the processing of their envelope glycoproteins. Zymogen activation of SKI-1/S1P involves sequential autocatalytic processing of its N-terminal prodomain at sites B'/B followed by… (More)
DOI: 10.1074/jbc.M114.588525

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@article{Palma2014ZymogenAA, title={Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease.}, author={Joel Ramos da Palma and Dominique Julien Burri and Jo{\"e}l Oppliger and Marco Salamina and Laura Cendron and Patrizia Polverino de Laureto and Nabil G Seidah and Stefan Kunz and Antonella Pasquato}, journal={The Journal of biological chemistry}, year={2014}, volume={289 52}, pages={35743-56} }