Zygotic Wnt/beta-catenin signaling preferentially regulates the expression of Myf5 gene in the mesoderm of Xenopus.

@article{Shi2002ZygoticWS,
  title={Zygotic Wnt/beta-catenin signaling preferentially regulates the expression of Myf5 gene in the mesoderm of Xenopus.},
  author={D L Shi and Audrey Bourdelas and Muriel Umbhauer and Jean-Claude Boucaut},
  journal={Developmental biology},
  year={2002},
  volume={245 1},
  pages={
          124-35
        }
}
Zygotic Wnt signaling has been shown to be involved in dorsoventral mesodermal patterning in Xenopus embryos, but how it regulates different myogenic gene expression in the lateral mesodermal domains is not clear. Here, we use transient exposure of embryos or explants to lithium, which mimics Wnt/beta-catenin signaling, as a tool to regulate the activation of this pathway at different times and places during early development. We show that activation of Wnt/beta-catenin signaling at the early… CONTINUE READING

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