Zygotic Genome Activation in Vertebrates.

@article{Jukam2017ZygoticGA,
  title={Zygotic Genome Activation in Vertebrates.},
  author={David Jukam and Seyed Ali Mohammad Shariati and Jan M Skotheim},
  journal={Developmental cell},
  year={2017},
  volume={42 4},
  pages={
          316-332
        }
}
The first major developmental transition in vertebrate embryos is the maternal-to-zygotic transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins. During the MZT, the embryo takes charge of gene expression to control cell differentiation and further development. This spectacular organismal transition requires nuclear reprogramming and the initiation of RNAPII at thousands of promoters. Zygotic genome activation (ZGA) is mechanistically coordinated with other embryonic… CONTINUE READING
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