Zwitterionic polycarboxybetaine coating functionalized with REDV peptide to improve selectivity for endothelial cells.

  title={Zwitterionic polycarboxybetaine coating functionalized with REDV peptide to improve selectivity for endothelial cells.},
  author={Ying Ji and Yu Wei and Xiangshen Liu and Jin-lei Wang and Ke‐feng Ren and Jian Ji},
  journal={Journal of biomedical materials research. Part A},
  volume={100 6},
  • Ying Ji, Yu Wei, J. Ji
  • Published 1 June 2012
  • Biology, Materials Science, Chemistry
  • Journal of biomedical materials research. Part A
Surface immobilization of bioactive molecules has been a promising strategy to develop in situ endothelialization for cardiovascular implants. With the aim to construct endothelial cell specific coating with low fouling property, zwitterionic carboxybetaine methacrylate and butyl methacrylate were copolymerized as coating materials, spin-coated onto substrates, and immobilized with endothelial cell selective peptide Arg-Glu-Asp-Val (REDV) through functionalization of carboxy groups in… 
Mussel-inspired triblock functional protein coating with endothelial cell selectivity for endothelialization.
A zwitterionic hydrogel coated titanium surface with high-efficiency endothelial cell selectivity for rapid re-endothelialization.
The antifouling and endothelial cell selective coating proposed in this work provides a promising strategy to develop an intravascular stent for promoted re-endothelialization and inhibited neointimal hyperplasia in clinical applications.
Multifunctional copolymer coating of polyethylene glycol, glycidyl methacrylate, and REDV to enhance the selectivity of endothelial cells
The copolymers containing GMA and PEG groups are very useful as a multifunctional coating material with anti-fouling and ECs specific adhesion for implant materials surface modification.
Multifunctional P(PEGMA)-REDV conjugated titanium surfaces for improved endothelial cell selectivity and hemocompatibility.
The results showed that the proliferation and attachment of human umbilical vein endothelial cells (HUVECs) were substantially improved by P(PEGMA)-REDV conjugation compared to pristine Ti surfaces, whilst no significant effects were observed for the mesenchymal stem cells (MSCs), thus confirming the selectivity of REDV for ECs.
Multifunctional REDV-conjugated zwitterionic polycarboxybetaine-polycaprolactone hybrid surfaces for enhanced antibacterial activity, anti-thrombogenicity and endothelial cell proliferation.
The current multifunctional PCL hybrid surface is potentially useful in tissue engineered constructs for vascular graft applications as it allows for better initial attachment and proliferation of ECs and improved hemocompatibility, whilst simultaneously reducing graft-associated infections.
Antimicrobial surfaces grafted random copolymers with REDV peptide beneficial for endothelialization.
The functionalized surfaces with high hydrophilicity and cell specific adhesive REDV peptide could selectively enhance the adhesion and proliferation of human umbilical vein endothelial cells but they suppressed these behaviors in human arterial smooth muscle cells (HASMCs).
Bioactive zwitterionic polymer brushes grafted from silicon wafers via SI-ATRP for enhancement of antifouling properties and endothelial cell selectivity
RedV-modified zwitterionic brushes had great potential for cardiovascular stent implantation and showed excellent EC selectivity after modification, according to this study.
Cellular attachment behavior on biodegradable polymer surface immobilizing endothelial cell-specific peptide
Biodegradable polymer surface immobilizing REDV peptide were prepared, and the specific attachment of endothelial cells on it was investigated as a preliminary study for tissue-engineered small-caliber blood vessels in a future application.


Bioactive microarrays immobilized on low-fouling surfaces to study specific endothelial cell adhesion.
Endothelial cells only were sensitive to RGD peptide co-immobilized with REDV or SVVYGLR sequences: they induced a reduction in cell spreading and a loss of actin stress fibers.
Dual-functional biomimetic materials: nonfouling poly(carboxybetaine) with active functional groups for protein immobilization.
We introduce a dual-functional biocompatible material based on zwitterionic poly(carboxybetaine methacrylate) (polyCBMA), which not only highly resists protein adsorption/cell adhesion, but also has
Fabrication and endothelialization of collagen-blended biodegradable polymer nanofibers: potential vascular graft for blood vessel tissue engineering.
Results showed that the collagen-blended polymer nanofibers could enhance the viability, spreading, and attachment of HCAECs and, moreover, preserve the EC phenotype.
Biofunctionalization of biomaterials for accelerated in situ endothelialization: a review.
The higher patency rates of cardiovascular implants, including vascular bypass grafts, stents, and heart valves are related to their ability to inhibit thrombosis, intimal hyperplasia, and
Bioconjugated phospholipid polymer biointerface for enzyme-linked immunosorbent assay.
This study aimed to develop a sensitive and reliable immunoassay by applying a highly functional phospholipid polymer biointerface that affords a low background without requiring blocking treatment and is suitable for immobilized antibodies.