Zwitterionic capsular polysaccharides: the new MHCII-dependent antigens.

@article{Cobb2005ZwitterionicCP,
  title={Zwitterionic capsular polysaccharides: the new MHCII-dependent antigens.},
  author={Brian A Cobb and Dennis L Kasper},
  journal={Cellular microbiology},
  year={2005},
  volume={7 10},
  pages={1398-403}
}
The immune system has evolved the ability for T cells to recognize nearly any biological polymer, including peptides, protein superantigens, and glycolipids through presentation by the major histocompatibility complex (MHC) proteins such as MHC class I (MHCI), MHC class II (MHCII), and CD1. A recent and unexpected addition to this list is the zwitterionic capsular polysaccharide (ZPS). These bacterial molecules utilize MHCII presentation to activate T cells via recognition by alphabeta T cell… CONTINUE READING

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