Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.

@article{Williams2003ZwilchAN,
  title={Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.},
  author={Byron C. Williams and Zexiao Li and Songtao Liu and Erika V. Williams and Garmay Leung and Tim J. Yen and Michael L Goldberg},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 4},
  pages={
          1379-91
        }
}
The Zeste-White 10 (ZW10) and Rough Deal (ROD) proteins are part of a complex necessary for accurate chromosome segregation. This complex recruits cytoplasmic dynein to the kinetochore and participates in the spindle checkpoint. We used immunoaffinity chromatography and mass spectroscopy to identify the Drosophila proteins in this complex. We found that the complex contains an additional protein we name Zwilch. Zwilch localizes to kinetochores and kinetochore microtubules in a manner identical… CONTINUE READING

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