Zscan4 regulates telomere elongation and genomic stability in ES cells

  title={Zscan4 regulates telomere elongation and genomic stability in ES cells},
  author={Michal Zalzman and Geppino Falco and Lioudmila V. Sharova and Akira Nishiyama and Marshall Thomas and Sung-Lim Lee and Carole A. Stagg and Hien G. Hoang and Hsih-Te Yang and Fred. E. Indig and Robert P. Wersto and Minoru S. H. Ko},
Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells. However, the genes contributing to this stability remain obscure. We previously identified Zscan4 as a specific marker for two-cell embryo and ES cells. Here we show that Zscan4 is involved in telomere maintenance and long-term genomic stability in ES cells. Only 5% of ES cells express Zscan4 at a given time, but nearly all ES cells activate Zscan4 at least once during nine passages. The transient Zscan4… CONTINUE READING
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