Zopiclone Overdose Responsive to Flumazenil

  title={Zopiclone Overdose Responsive to Flumazenil},
  author={John J. Cienki and Keith K. Burkhart and J. Ward Donovan},
  journal={Clinical Toxicology},
  pages={385 - 386}
Zopiclone facilitates GABA-A transmission in the central nervous system. Zopiclone’s binding site appears to be distinct from that of the benzodiazepines but photoaffinity labeling and analysis of the allosteric modification of GABA suggest that the sites are adjacent and may overlap (1). A MEDLINE literature search (key words: zopiclone, cyclopyrrolones) revealed no cases that involved successful reversal of the drug effects with an antidote. We report the first zopiclone overdose that… Expand

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