Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses.

@article{Marinaro2003ZonulaOT,
  title={Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses.},
  author={M Marinaro and Alessio Fasano and Maria Teresa De Magistris},
  journal={Infection and immunity},
  year={2003},
  volume={71 4},
  pages={1897-902}
}
Zonula occludens toxin (Zot) is produced by Vibrio cholerae and has the ability to increase mucosal permeability by reversibly affecting the structure of tight junctions. Because of this property, Zot is a promising tool for mucosal drug and antigen (Ag) delivery. Here we show that Zot acts as a mucosal adjuvant to induce long-lasting and protective immune responses upon mucosal immunization of mice. Indeed, the intranasal delivery of ovalbumin with two different recombinant forms of Zot in… CONTINUE READING
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