Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells.

@article{Meyer2002ZonulaOI,
  title={Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells.},
  author={Tobias N. Meyer and Catherine Schwesinger and Bradley M Denker},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 28},
  pages={24855-8}
}
Zonula occludens proteins are multidomain proteins usually localized at sites of intercellular junctions, yet little is known about their role in regulating junctional properties. Multiple signaling proteins regulate the junctional complex, and several (including G proteins) have been co-localized with zonula occludens-1 (ZO-1) in the tight junction of… CONTINUE READING