Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats

@article{Hamada2010ZonulaOA,
  title={Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats},
  author={Kazuma Hamada and Yoshihisa Shitara and Shuichi Sekine and Toshiharu Horie},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2010},
  volume={66},
  pages={1031-1038}
}
The molecular mechanisms that underlie the methotrexate (MTX)-mediated disruption of intestinal barrier function have not been fully characterized. Epithelial barrier function is determined in large part by a multiprotein complex located at the most apical part of the lateral membrane, which is referred to as a tight junction (TJ). In the present study, we examined the alteration of zonula occludens-1 (ZO-1), which is a scaffolding protein that plays a pivotal role in the formation of TJs, to… CONTINUE READING
24 Extracted Citations
38 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 24 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 38 references

Similar Papers

Loading similar papers…