Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.

@article{Kawajiri2010ZonisamideRC,
  title={Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.},
  author={Sumihiro Kawajiri and Yutaka Machida and Shinji Saiki and Shigeto Sato and Nobutaka Hattori},
  journal={Neuroscience letters},
  year={2010},
  volume={481 2},
  pages={88-91}
}
Zonisamide, originally known as an antiepileptic drug, has been approved in Japan as adjunctive therapy with levodopa for the treatment of Parkinson's disease (PD). Although zonisamide reduces neurotoxicity, the precise mechanism of this action is not known. Here, we show that zonisamide increases cell viability in SH-SY5Y cells via an anti-apoptotic effect and by upregulating levels of manganese superoxide dismutase (MnSOD). These results would give us novel evidences of PD treatment. 
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Therapeutic effect of a novel anti - parkinsonian agent zonisamide against MPTP ( 1 - methyl - 4 - phenyl - 1 , 2 , 3 , 6 - tetrahydropyridine ) neurotoxicity in mice

  • R. Yano Yokoyama, H. Kuroiwa, +4 authors T. Araki
  • Metab . Brain Dis .
  • 2010

isamide increases dopamine turnover in the striatum of mice and common marmosets treated with MPTP

  • M. E. Choudhury Yabe, M. Kubo, N. Nishikawa, M. Nagai, M. Nomoto
  • J . Pharmacol . Sci .
  • 2009

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