Zonisamide improves motor function in Parkinson disease

@article{Murata2007ZonisamideIM,
  title={Zonisamide improves motor function in Parkinson disease},
  author={Miho Murata and Kazuko Hasegawa and Ichiro Kanazawa},
  journal={Neurology},
  year={2007},
  volume={68},
  pages={45 - 50}
}
Objective: To evaluate the efficacy, safety and tolerability of daily doses of 25, 50, and 100 mg of zonisamide (ZNS) administered as adjunctive treatment in patients with Parkinson disease (PD). Methods: We conducted a multicenter, randomized, double-blind, parallel-treatment, placebo-controlled study in Japan. Patients with PD who showed insufficient response to levodopa treatment were given placebo for 2 weeks and then treated for 12 weeks with 25, 50, or 100 mg/day of ZNS or placebo, in… Expand
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References

SHOWING 1-10 OF 19 REFERENCES
Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial
TLDR
Once-daily rasagiline reduces mean daily off-time and improves symptoms of Parkinson's disease in levodopa-treated patients with motor fluctuations, an effect similar to that of entacapone. Expand
Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease.
  • M. Murata
  • Medicine
  • Current pharmaceutical design
  • 2004
TLDR
It is suggested that the activation of dopamine synthesis and the moderate level of MAOB inhibition are main mechanisms of ZNS effects on PD. Expand
Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol.
TLDR
Although the number of enrolled patients was limited, this open-label pilot study suggests that ZNS may have a therapeutic potential for essential tremor and a controlled trial of this drug in the future would be valuable. Expand
Zonisamide has beneficial effects on Parkinson's disease patients
TLDR
It is speculated that long lasting activation of dopamine synthesis by ZNS ameliorates parkinsonian symptoms, in particular wearing-off. Expand
Intermittent vs continuous levodopa administration in patients with advanced Parkinson disease: a clinical and pharmacokinetic study.
TLDR
This study confirms that a continuous levodopa infusion is associated with reduced motor complications compared with the standard oral formulation of the drug in patients with advanced PD. Expand
Randomized, double‐blind study of pramipexole with placebo and bromocriptine in advanced Parkinson's disease
We compared the efficacy and safety of pramipexole (PPX) with placebo in the treatment of advanced Parkinson's disease (PD) as an adjunct to levodopa. A bromocriptine (BR) group was included toExpand
Effects of zonisamide on dopaminergic system
TLDR
It is suggested that therapeutic ZNS doses increase DOPA accumulation as well as both intracellular and extracellular DA, DOPA and HVA levels, and that acute and chronic supratherapeutic ZNS dose administrations inhibit DA turnover. Expand
Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson’s activity
TLDR
Results support previously reported findings and provide additional evidence that the anticonvulsant ZNS appears to possess anti-Parkinson’s properties and could be a novel agent for the treatment of PD that could delay the use of or reduce the amount of levodopa needed to treat patients with PD. Expand
Effects of zonisamide on extracellular levels of monoamine and its metabolite, and on Ca2+ ependent dopamine release
TLDR
The present results suggest that zonisamide facilitates dopaminergic and serotoninergic neurotransmission but does not affect Ca2+ dependent dopamine release within therapeutic plasma concentrations. Expand
Mechanisms of T-type calcium channel blockade by zonisamide
TLDR
The blockade of T-type calcium channels by zonisamide could suppress an important component of inward current that underlies epileptiform cellular bursting, thereby inhibiting the spread of seizure activity. Expand
...
1
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