Zone-Dependent Expression of Estrogen Receptors α and β in Human Benign Prostatic Hyperplasia

@article{Tsurusaki2003ZoneDependentEO,
  title={Zone-Dependent Expression of Estrogen Receptors $\alpha$ and $\beta$ in Human Benign Prostatic Hyperplasia},
  author={Toshifumi Tsurusaki and Daiyu Aoki and Hiroshi Kanetake and Satoshi Inoue and M. Muramatsu and Yoshitaka Hishikawa and Takehiko Koji},
  journal={The Journal of Clinical Endocrinology and Metabolism},
  year={2003},
  volume={88},
  pages={1333-1340}
}
  • T. Tsurusaki, D. Aoki, +4 authors T. Koji
  • Published 1 March 2003
  • Biology, Medicine
  • The Journal of Clinical Endocrinology and Metabolism
Estrogen, which acts through estrogen receptors (ERs) α and β, has been implicated in the pathogenesis of benign and malignant human prostatic tumors, i.e. benign prostatic hyperplasia and prostate cancer, thought to originate from different zones of the prostate [the transition zone (TZ) and peripheral zone (PZ), respectively]. Here, we examined the cellular distribution of ERα and ERβ in human normal and hyperplastic prostate tissues, using in situ hybridization and immunohistochemistry. ER… 
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Results Citations
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The activation of AR and PGR and repression of ERα in BPH are identified, which indicate a promoting role ofAR and P GR and an inhibitory role of ERβ in the pathogenesis of BPH.
Involvement of estrogen receptors in prostatic diseases
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    International journal of urology : official journal of the Japanese Urological Association
  • 2012
TLDR
Estrogen receptor-mediated signaling in the prostate is essential together with the androgen receptor‐mediated pathway, providing a new therapeutic target for prostatic diseases.
Expression of estrogen alpha and beta receptors in prostate cancer and hyperplasia: Immunohistochemical analysis
TLDR
The majority of PCa and BPH exhibited nuclear immunoreactivity for ER-β in both tumor and stromal cells and they are usually negative for ER -α, which may have a role in the process of prostatic hyperplasia and malignancy.
Estrogen regulates the proliferation and inflammatory expression of primary stromal cell in benign prostatic hyperplasia.
TLDR
The expressions of ER in human BPH prostate tissues are zone-dependent, and estrogen promoting the proliferation of primary prostate stromal cells cultured in DMEM supplemented with 2% FBS.
Immunohistochemical analysis of estrogen receptors in prostate and clinical correlation in men with benign prostatic hyperplasia
TLDR
Strong immunostaining for ERα in stroma and for ERβ in epithelium is found and ERs may play an important role in the pathogenesis of BPH, finding a significant correlation between prostatic ER levels and various clinical measures of B PH.
A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia
TLDR
It is concluded that BPH is not a disease of prostatic stromal proliferation but rather of accumulation of mesenchymal-like cells derived from the prostatic epithelium and the endothelium, and TGF-β is thought to play a key role in EMT.
Sex steroid receptor expression and localization in benign prostatic hyperplasia varies with tissue compartment.
Estrogen Action in Normal Prostate Epithelium and in Prostate Cancer
TLDR
The evidence for a role of estrogens and specific ERs in prostate growth, differentiation, and carcinogenesis is reviewed as well as potential therapeutic strategies for growth regulation via these pathways are discussed.
Changes in Estrogen Receptor ERβ (ESR2) Expression without Changes in the Estradiol Levels in the Prostate of Aging Rats
TLDR
A pioneering study that reveals focal ERβ reduction in the prostate of aging rats and indicates a potential disorder in the ERβ pathway, corroborate previous data from humans and dogs that silencing of this receptor may be associated with premalignant or malignant conditions in the gland.
Expression of Androgen, Oestrogen α and β, and Progesterone Receptors in the Canine Prostate: Differences between Normal, Inflamed, Hyperplastic and Neoplastic Glands
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