Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole.

@article{Fang1998ZonatedEO,
  title={Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole.},
  author={Che Fang and Kai O. Lindros and T M Badger and Martin J. J. Ronis and Magnus Ingelman-Sundberg},
  journal={Hepatology},
  year={1998},
  volume={27 5},
  pages={1304-10}
}
The release of proinflammatory cytokines by endotoxins and during oxidative stress is considered to be an early key step in the pathogenesis of alcoholic liver disease (ALD). Ethanol-inducible cytochrome P450 2E1 (CYP2E1) has potentially pro-oxidative and toxicological properties, and its expression is restricted to the perivenous region of liver. We investigated zonal differences of cytokine expression in rat liver and how these are affected by alcohol exposure and by chlormethiazole (CMZ), a… CONTINUE READING
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